Guo Laboratory
Department of Neuroscience  |  Yale School of Medicine

Lab members are highlighted in bold; *, equal contribution; #, corresponding author


  •  ​​Sun Y, Eshov A, Guo JU#, C9orf72 dipeptide repeats inhibit UPF1-mediated RNA decay independent of stress granule formation. bioRxiv​​

​​Before 2017
​ (selected)

  •  ​​Guo JU, Bartel DP, RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria. Science (Research Article), 2016 Sep 23;353(6306):aaf5371. PMID:27708011
    Highlighted in Chemical & Engineering News , Nature Chemical Biology , Scivit News , The Scientist
  • Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P, Song H, Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell, 2016 Jan 7;61(1):153-60. PMID:26711009

  • Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Ming GL, Song H, Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience, 2015 Jun;18(6):836-43. PMID:25915473

  • Guo JU, Agarwal V, Guo H, Bartel DP, Expanded identification and characterization of mammalian circular RNAs. Genome Biology, 2014 Jul 29;15(7):409. PMID:25070500

  • Guo JU*, Su Y*, Shin JH, Xie B, Zhong C, Shin J, Li H, Hu S, Le T, Fan G, Zhu H, Chang Q, Ming GL, Gao Y, Song H, Distribution, recognition and regulation and non-CpG methylation in the adult mammalian brain. Nature Neuroscience, 2014 Feb;17(2):215-22. PMID: 24362762

  • Yeo M, Berglund K, Hanna M, Guo JU, Kittur J, Abramowitz J, Busciglio J, Gao Y, Birnbaumer L, Liedtke WB, Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2/Slc12a5 promoter. Proc Natl Acad Sci U S A., 2013 Mar 12;110(11):4315-4320. PMID:23440186

  • Jang MH, Bonaguidi MA, Kitabatake Y, Sun J, Song J, Kang E, Jun H, Zhong C, Su Y, Guo JU, Wang MX, Sailor KA, Kim JY, Gao Y, Christian KM, Ming GL, Song H, Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell, 2013 Feb 7;12(2):215-23. PMID:23395446

  • Kang E, Burdick KE, Kim JY, Duan X, Guo JU, Sailor KA, Jung DE, Ganesan S, Choi S, Pradhan D, Lu B, Dimitrios A, Christian K, Malhotra AK, Song H, Ming GL, Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron, 2011 Nov 17; 72(4):559-71. PMID:22099459

  • Guo JU, Ma DK, Mo H, Ball MP, Jang MH, Bonaguidi MA, Balazer JA, Eaves HL, Xie B, Ford E, Zhang K, Ming GL, Gao Y, Song H, Neuronal activity modifies the DNA methylation landscape in the adult brain. Nature Neuroscience (cover article), 2011 Aug 28;14(10):1345-51. PMID:21874013

  • Guo JU, Su Y, Zhong C, Ming GL, Song H, Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (cover article), 2011 Apr 29; 145(3):423-34. PMID:21496894

  • Guo JU, Su Y, Zhong C, Ming GL, Song H, Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond. Cell Cycle, 2011 Aug 15; 10(16):2662-8. PMID:21811096

  • Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H, Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nature Neuroscience, 2010 Nov;13(11):1338-44. PMID:20975758

  • Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming GL, DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron, 2009 Sep 24; 63(6): 761-773 PMID:19778506

  • Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-anpongkul N, Flavell RA, Lu B, Ming GL, Song H, Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science, 2009 Feb 20;323(5917):1074-7. PMID:19119186