Guo Lab @ Yale
Department of Neuroscience  |  Yale School of Medicine

News

12/1/2017
Aziz Eshov joins the lab. He received his B.Sc. in Neuroscience from Emory University. Welcome, Aziz!

12/1/2017
Dr. Yu Sun joins the lab. She recently received her PhD at the Chinese Academy of Sciences, where she studied long noncoding RNA functions. Welcome, Dr. Sun!

11/21/2017
Dr. Guo was named a Yale Scholar in Neurodegenerative Research. Congratulations!
http://medicine.yale.edu/news/article.aspx?id=16226

9/1/2017
The lab is officially open!

RNA Biology in the Nervous System
We are fascinated by numerous questions at the intersection of neuroscience and RNA biology.  
Currently, we are investigating the roles of RNA structures in neuronal development, homeostasis, and neurological diseases, taking a combination of computational, biochemical, genetic, and genomic approaches.​

Pathogenic
RNA repeats
Localization of neuronal mRNAs
Noncoding RNA
functions
A variety of neurological disorders, including myotonic dystrophy, amyotrophic lateral sclerosis (a.k.a. Lou Gehrig’s disease) and frontotemporal dementia, are caused by the expansion of nucleotide repeats in the genome. The RNA repeats transcribed from these loci exhibit unusual properties. For example, some repeats undergo phase seperation and form distinct foci, which may sequester certain RNA-binding proteins. Some RNA repeats are translated into toxic polypeptides via a noncanonical mechanism. We aim to determine the causes of these unusual properties and their contributions to the disease phenotypes, with the goal of developing novel  therapeutics.
  Spatially precise regulation of gene expression is critical for morphologically complex cells. In neurons, this is achieved in part through the localization of mRNAs to distal compartments in dendrites and axons. Although mRNA localization and local translational control are known to play important roles in neuronal development and plasticity, we do not fully understand the cis-regulatory elements (often being secondary structures) in mRNAs that determine their localization and how these elements function. We aim to systematically identify these structural elements as well as the proteins that mediate their functions.
Since the advent of high-throughput DNA sequencing technologies, the identification of the cellular repertoire of noncoding RNAs has vastly outpaced our understanding of their biological functions. Of the many thousands of small RNAs and long noncoding RNAs in cells, only a small fraction has been functionally characterized. We are interested in developing new tools to interrogate their functions during development of the mammalian nervous system.
Publications
Join Us
We aspire to create a diverse, stimulating, and collaborative lab environment. Motivated scientists of all stages and all backgrounds are welcome to join our growing team!
Graduate students are recruited through the Yale Biological and Biomedical Sciences (BBS) program.
Our lab is affiliated with both  Neuroscience  and ​ Molecular Cell Biology, Genetics, and Development  tracks.  

Please contact Junjie to discuss current rotation projects.
Postdoctoral positions are currently available. Start date is flexible. Candidates should have received a doctoral degree no more than 2 years before the start date. Researchers with a passion in RNA biology and neuroscience, regardless of their training background, are welcome to apply.  Expertise in any of the following areas is highly valued though not required:

  • Mouse/fly genetics
  • Experimental models of neurodevelopment or neurodegeneration
  • Advanced imaging techniques 

Please email your application to junjie dot guo at yale dot edu, including:

  • A cover letter describing your past training, research interests and career goals
  • A detailed CV
  • Contact information of referees